Congratulations to recent graduates, Andrea Durant (PhD) and Elia Grieco Guardian (MSc) for obtaining their graduate degrees.
Category: Uncategorized
November, 2020; Ammonium Transporter in sperm of mosquito affects fertility
In a recent publication in PNAS, PhD Candidate Andrea Durant demonstrated that an ammonium transporter, AeAmt1 is expressed in sperm and is important for sperm survival and male fertility. [Article]
| Summary: A group of related specialized channels that transport ammonia are found in all domains of life including plants, bacteria, and animals. Plants use these ammonia channels to take up ammonia that they need from the soil, but in animals, ammonia is toxic if it accumulates. Animals produce ammonia as a by-product of protein digestion and excrete it either as-is or after converting it to less toxic forms, such as urea or uric acid. The ammonia channels in animals are used to shuttle ammonia out of cells and tissues for excretion. In this study, we planned to examine and understand the role that an ammonia channel (Aedes aegypti Ammonium Transporter protein 1, AeAmt1) plays during digestion of a protein-rich blood meal in mosquitoes that spread the diseases Dengue, Chikungunya, and Zika. We expected to find high AeAmt1 expression in digestive and excretory organs, important sites for protein digestion, and ammonia excretion. To our surprise, we found AeAmt1 most highly present in an organ called spermatheca in female mosquitoes (and many other species of insects). The spermathecae are organs where sperm is stored within the female mosquito after mating with a male mosquito and before egg fertilization. This finding then led us to examine the male mosquitoes, where we found that AeAmt1 is found within the sperm, specifically. Our further studies demonstrated that AeAmt1 is essential for sperm survival and male fertility in these mosquitoes. With this knowledge, AeAmt1 may be exploited to control populations of these disease-spreading mosquitoes. Perhaps more importantly, we have discovered a new role for ammonia channels in mosquitoes in the context of reproduction. |
December 20, 2019
Congratulations Andrea Durant on reporting the results of your field study in the British Virgin Islands that shows how mosquitoes adjust their physiology to live in poop! See: Nature: Scientific Reports 9,19028 (2019).
August 29, 2019
Elia Grieco Guardian, Congratulations on receiving an NSERC Canada Graduate Scholarship.
August 29, 2019
Fargol Nowghani, Congratulations on your MSc thesis, awarded with high distinction and published in Aquatic Toxicology. Best wishes in Dental School at Trinity College, Dublin.
June 21, 2018
Congratulations to Lidiya Misyura on her Masters degree. Lidiya’s thesis will be conferred with high distinction and nominated for the yearly thesis prize. Best wishes to Lidiya on her next endeavour at the University of Toronto Mississauga’s Master of Management of Innovation and her future goals.
June 13, 2018
Congratulations to Gil Yerushalmi for defending his MSc thesis which is published in the Journal of Experimental Biology. The examination committee recommended awarding Gil’s MSc with high distinction with a nomination for the yearly thesis prize. Best Wishes to Gil as he embarks on his next challenge, surviving a trip to southeast Asia and then Med School at U of T.
April 17, 2018
We would like to thank Peter Piermarini for organizing the OARDC Mosquito Conference 2018 and inviting us to participate. It was a great meeting!
April 11, 2018
Congratulations to the talented people in the lab:
Congratulations to Andrea Durant who was offered an Ontario Graduate Scholarship.
Congratulations to Lidiya Misyura who was offered an Ontario Graduate Scholarship, an NSERC Post Graduate Scholarships -Doctoral Program, and a position in the Master of Management of Innovation Program at UTM!! A collection of exceptional achievements!
Congratulations to Fargol Nowghani who was offered an NSERC Canada Graduate Scholarships – Master’s Program.
March 21, 2018
Fargol Nowghani presented her recent work on the effects of salt pollution on mayfly larval physiology at the 2nd Biennial Mayfly Symposium in the Best in Science Symposium series organized and funded by the Ontario Ministry of the Environment and Climate Change. Thank you Trudy Watson Leung for organizing a great day of mayfly research.